Nanotechnology, Carbon Tubes, and Asbestosis


By nycowboy, Section Diaries
Posted on Wed May 21, 2008 at 09:37:08 AM EST

This study was released in Nature Magazine although it's not available online for free:


Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study

Carbon nanotubes1 have distinctive characteristics2, but their needle-like fibre shape has been compared to asbestos3, raising concerns that widespread use of carbon nanotubes may lead to mesothelioma, cancer of the lining of the lungs caused by exposure to asbestos4. Here we show that exposing the mesothelial lining of the body cavity of mice, as a surrogate for the mesothelial lining of the chest cavity, to long multiwalled carbon nanotubes results in asbestos-like, length-dependent, pathogenic behaviour. This includes inflammation and the formation of lesions known as granulomas. This is of considerable importance, because research and business communities continue to invest heavily in carbon nanotubes for a wide range of products5 under the assumption that they are no more hazardous than graphite. Our results suggest the need for further research and great caution before introducing such products into the market if long-term harm is to be avoided.

Scientific America describes it as:


Inhaling carbon nanotubes could be as harmful as breathing in asbestos, and its use should be regulated lest it lead to the same cancer and breathing problems that prompted a ban on the use of asbestos as insulation in buildings, according a new study posted online today by Nature Nanotechnology.

During the study, led by the Queen's Medical Research Institute at the University of Edinburgh/MRC Center for Inflammation Research (CIR) in Scotland, scientists observed that long, thin carbon nanotubes look and behave like asbestos fibers, which have been shown to cause mesothelioma , a deadly cancer of the membrane lining the body's internal organs (in particular the lungs) that can take 30 to 40 years to appear following exposure. Asbestos fibers are especially harmful, because they are small enough to penetrate deep into the lungs yet too long for the body's immune system to destroy.

The researchers reached their conclusions after they exposed lab mice to needle-thin nanotubes: The inside lining of the animals' body cavities became inflamed and formed lesions.

And New York Times:


An article published Tuesday on the Web site of the journal Nature Nanotechnology suggests that the answer may be yes. A team of researchers reported that injecting nanotubes into the abdomens of mice induced lesions similar to those that appear on the outer lining of the lungs after the inhalation of asbestos.

In the case of asbestos, the lesions eventually become mesothelioma, a deadly cancer.

The researchers, though, portrayed their results as good news by providing people who work with nanotubes with knowledge of how to minimize the dangers.

"In a sense, we're forewarned and forearmed now with respect to nanotubes," said Anthony Seaton, a professor of environmental and occupational medicine at the University of Aberdeen in Scotland.

Vicki Colvin, a professor of chemistry at Rice University in Houston, who was not involved with the research, said that she saw no need to restrict the use of nanotubes in products, but that their use should be better labeled.

"I'm not alarmed," Professor Colvin said, "but it seems we should have better information about where it is and how it's being used."

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Nanotechnology, Carbon Tubes, and Asbestosis | 4 comments (4 topical, 0 hidden)
Nano != Nano (none / 0) (#1)
by AlfredMoisiu on Wed May 21, 2008 at 10:40:45 AM EST
What you're getting worked up about is nanoparticles, which are not being used for applications where humans would exposed to them.

Albany Nanotech is working on perfecting processeses using nanolithography, which is essentially a process of etching very small (ie nano-scale) structures on silicon, germanium and other materials for semiconductors.


Gee, Al M, just when we were getting along ... (none / 0) (#2)
by Jim Travers on Wed May 21, 2008 at 08:41:38 PM EST
so well, you have to go and say something stupid like this: "What you're getting worked up about is nanoparticles, which are not being used for applications where humans would exposed to them."

First of all, Andy is simply reporting news items. Without him commenting, I cannot see how you've determined he's "getting all worked up".

While you are correct in mentioning the school and its associated businesses are perfecting nanolithograpy, that is only one technology they are working on. Do you really believe all 250 businesses afilliated with the campus are engaged in this one technology?

Perhaps you are not getting yourself worked up
about the health dangers posed by nanotechnology, because you under under a wrong impression of what these technologies are actually developing in addition to the electrical engineering known as nanolithography. But it seems some scientists and environmentals are.

Nanotechnology does indeed incorporate the use of nanoparticles.

"Nanotechnology is the science of managing and manipulating matter at the atomic level. "Nano" refers to nanometer, or one billionth of a meter, the length scale used to depict atomic dimensions."

A Nanometer is a billionth of a meter or (10 exponent -9) and is one thousand times smaller than a Micrometer which is a millionth of a meter (10 exponent -6). Nm 0.000000001; Mm 0.000001

The reason I mention these dimensions will become obvious after reading the article below.

"The behavior of materials at the nanoscale is often very different from when they are in a larger form. Nanomaterials can be stronger, lighter," ... "and are often able to conduct heat or electricity in a different way. They can even change color."

"These special attributes are already being used in a number of ways, such as in semiconductors, scratch-free paint, wrinkle and stain-resistant fabrics, sunscreen lotions, skis and photographic paper." (Emphasis added)

http://cnse.albany.edu/

It is also apparent that you didn't even read the full text at the wiki link you provided, for had you, you might have noted there this:

"Safety Issues
Nanoparticles present possible dangers, both medically and environmentally. Most of these are due to the high surface to volume ratio, which can make the particles very reactive or catalytic. They are also able to pass through cell membranes in organisms, and their interactions with biological systems are relatively unknown. However, free nanoparticles in the environment quickly tend to agglomerate and thus leave the nano-regime, and nature itself presents many nanoparticles to which organisms on earth may have evolved immunity (such as salt particulates from ocean aerosols, terpenes from plants, or dust from volcanic eruptions). A fuller analysis is provided in the article on nanotechnology.

According to the San Francisco Chronicle, "Animal studies have shown that some nanoparticles can penetrate cells and tissues, move through the body and brain and cause biochemical damage. But whether cosmetics and sunscreens containing nanomaterials pose health risks remains largely unknown, pending completion of long-range studies recently begun by the FDA and other agencies." Diesel nanoparticles have been found to damage the cardiovascular system in a mouse model."

But then, I suppose you might not have because you misunderstood the technology or only understood one aspect of it. Nanoparticles are both naturally occuring and man-made.

The dangers posed by nanoscience have been being researched since the early 1990s. This field of research has been dubbed Nanotoxicology.

"Nanoparticle seem to have some different properties from larger particles that are known to have pathogenic effects , like asbestos or quartz. These differences seem to be a result of their size. They have a larger surface area per unit mass and this means that in some cases they may have more pro-inflammatory effects in, e.g. the lungs. In addition, some seem to be able to translocate from their site of deposition to distant sites such as the blood and the brain. This has resulted in a sea-change in how particle toxicology is viewed- instead of being confined to the lungs, nanoparticle toxicologists study the brain, blood, liver, skin and gut. Nanotoxicology has revolutionised particle toxicology and rejuvenated it."

http://en.wikipedia.org/wiki/Nanotoxicology

The article I referred to earlier was published by Newsday in 2006. It speaks to particulate matter up to 2.5 thousand times greater in size than a nanometer.

Particles a big problem
Heart, lung patients who inhale fragments of pollutants face a greater risk of hospital stay, research shows

BLOOMBERG NEWS

March 8, 2006

Older heart- and lung-disease patients exposed to pollution particles smaller than a strand of hair for a few days face more admissions to the hospital, according to a study published today.

The fine particles, a 30th the diameter of a hair or smaller, have a greater chance of penetrating into a person's airways, increasing the risk of disease, said researcher Francesca Dominici, associate professor of biostatistics at Johns Hopkins University's Bloomberg School of Public Health.

The study of admission rates for 11.5 million patients 65 and older looked at particles measuring 2.5 micrometers (0.0000025 meters) or less.

When they invade the lung, the particles "may promote inflammation and thereby exacerbate underlying lung disease and reduce the efficacy of lung-defense mechanisms," the researchers said.

"I was surprised by the consistency and magnitude of the risk," Dominici said in an interview before the study's publication in the Journal of the American Medical Association today.

Previous research showed larger particles increased hospital admissions. The patients, enrolled in the federally run Medicare plan, were admitted for cardiovascular or respiratory diseases or injuries. The injury category wasn't affected by the pollution particles, she said.

The patients studied from 1999 through 2002 showed the biggest association between pollution exposure and heart failure, which increased 1.28 percent for every 10 micrograms per cubic meter gain in small particles, according to the study.

Heart disease may come from the particles' impact on nerve tissue or inflammatory processes.

The annual hospital admissions for heart-failure patients would have dropped 1.3 percent to 243,442 in 2002 if the pollution particles had been reduced by 10 micrograms per cubic meter a day, Dominici said.

The study of patients from 204 U.S. urban counties with populations more than 200,000 showed cardiovascular risks were higher in the Northeast, Dominici said.

Pollution there comes from coal-burning power plants, automobiles, factories, agriculture activities and sunlight and water vapor reacting with gases, she said.

"The next step is to find out what sources are more toxic," Dominici said."

Remember Buckyballs? (none / 0) (#3)
by Dan Van Riper on Fri May 23, 2008 at 05:31:01 AM EST

Just like nanotubes, buckyballs were the next big industrial miracle material.  They are basically carbon molecules arranged in a ball with a hollow interior.  Not only were they supposed to be the building blocks for new and better materials, they were supposed to be a new way to deliver life saving drugs to the proper places within the human body.

Except for one problem.  When they get inside the body, either deliberately or through our drinking water, they rip your brain to shreds.  Oops!

http://www.newscientist.com/article/dn4825-buckyballs-cause-brain-damage-in-fish.html

Thus I am hardly shocked to hear that the next big industrial miracle material nanotubes are also an environmental nightmare.

Let's all be thankful that we still have enough freedom of speech via the First Amendment that we can still hear the truth about these "miracles" before they kill us.

Buckminsterfullerene was once the correct name (none / 0) (#4)
by Jim Travers on Fri May 23, 2008 at 07:23:28 AM EST
of buckyballs, and were named after one of my idols, R. Buckminster Fuller, the famed architect who invented the geodesic dome, because they resembled those structures. After the discovery of the fullerene family of structures, which came later than the discovery of buckminsterfullerenes, the name was shortened to buckyballs. Buckyballs are comprised of sixty carbon atoms.

Nanotechnology, Carbon Tubes, and Asbestosis | 4 comments (4 topical, 0 hidden)
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